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Promega prl-cmv vectors
Prl Cmv Vectors, supplied by Promega, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/prl-cmv+vectors/prl+cmv+plasmid/pm40639948-317-5-10
Average 90 stars, based on 1 article reviews
prl-cmv vectors - by Bioz Stars, 2026-10
90/100 stars

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Related Articles

Luciferase:

Article Title: Long Noncoding RNA HOTAIR: An Oncogene in Human Cervical Cancer Interacting With MicroRNA-17-5p
Article Snippet: In the preparatory stage, wild-type (WT) or mutant-type (MUT) 3′-UTR sequences of HOTAIR were inserted at the firefly luciferase gene in pRL-CMV vectors (Promega, Madison, WI, USA), purified, and named as reporter mimics.

Article Title: Long Noncoding RNA HOTAIR: An Oncogene in Human Cervical Cancer Interacting With MicroRNA-17-5p
Article Snippet: In addition, pRL-CML vectors carrying the Renilla luciferase gene were applied in every sample as internal control for transfection efficiency (Promega).

Article Title: High glucose/ChREBP-induced Hif-1α transcriptional activation in CD4 + T cells reduces the risk of diabetic kidney disease by inhibiting the Th1 response.
Article Snippet: Dual luciferase reporter assay 293T cells were cultured in 24 well plates overnight and then transfected with the pGL3 vector reporter construct and pRL-CMV vectors (Promega, USA) encoding Renilla luciferase using lipofectamine 2000 reagent (Invitrogen).

Article Title: Long Noncoding RNA HOTAIR: An Oncogene in Human Cervical Cancer Interacting With MicroRNA-17-5p
Article Snippet: Please use proper citation format when citing this article including the DOI, publisher reference, volume number and page location. (MUT) 3¢-UTR sequences of HOTAIR were inserted at the firefly luciferase gene in pRL-CMV vectors (Promega, Madison, WI, USA), purified, and named as reporter mimics.

Article Title: Differential response of nucleus pulposus intervertebral disc cells to high salt, sorbitol, and urea.
Article Snippet: Nucleus pulposus intervertebral disc cells are routinely confronted with high osmolality in their microenvironment and respond to this stress in vitro by regulating cell cycle progression and by activating a DNA repair machinery in order to counteract its genotoxic effect.. In the present study, we attempted to identify the origin of this osmo-regulatory response, by using an ionic NaCl/KCl solution, the compatible osmolyte sorbitol, and the readily permeant urea.. High salt and sorbitol were found to activate similar molecular pathways, including the p38MAPK and the p53-p21-pRb axis, thatwere not stimulated by high urea.On the other hand, only high urea led to the phosphorylation of ERKs and JNKs.

Article Title: STK25 is an IRF5 kinase that promotes TLR7/8-mediated inflammation
Article Snippet: The pGL3-ISRE-Luc vector and the pRL-CMV vectors were obtained from Promega.

Article Title: TLR-induced STK25 activation promotes IRF5-mediated inflammation.
Article Snippet: The pGL3-ISRE-Luc vector and the pRL-CMV vectors were obtained from Promega.

Article Title: Ribosomal protein S15a promotes tumor angiogenesis via enhancing Wnt/β-catenin-induced FGF18 expression in hepatocellular carcinoma.
Article Snippet: Ribosomal protein s15a (RPS15A) plays a promotive role in the mRNA/ribosome interactions during early translation.. Our previous study has found that inhibiting RPS15A expression can decrease proliferation and induce cell cycle arrest in hepatocellular carcinoma (HCC) cell lines.. However, the mechanism underlying the involvement of RPS15A in HCC pathogenesis and the clinical significance of RPS15A expression remain unclear.

Reporter Assay:

Article Title: Long Noncoding RNA HOTAIR: An Oncogene in Human Cervical Cancer Interacting With MicroRNA-17-5p
Article Snippet: In the preparatory stage, wild-type (WT) or mutant-type (MUT) 3′-UTR sequences of HOTAIR were inserted at the firefly luciferase gene in pRL-CMV vectors (Promega, Madison, WI, USA), purified, and named as reporter mimics.

Article Title: Long Noncoding RNA HOTAIR: An Oncogene in Human Cervical Cancer Interacting With MicroRNA-17-5p
Article Snippet: In addition, pRL-CML vectors carrying the Renilla luciferase gene were applied in every sample as internal control for transfection efficiency (Promega).

Article Title: High glucose/ChREBP-induced Hif-1α transcriptional activation in CD4 + T cells reduces the risk of diabetic kidney disease by inhibiting the Th1 response.
Article Snippet: Dual luciferase reporter assay 293T cells were cultured in 24 well plates overnight and then transfected with the pGL3 vector reporter construct and pRL-CMV vectors (Promega, USA) encoding Renilla luciferase using lipofectamine 2000 reagent (Invitrogen).

Article Title: Long Noncoding RNA HOTAIR: An Oncogene in Human Cervical Cancer Interacting With MicroRNA-17-5p
Article Snippet: Please use proper citation format when citing this article including the DOI, publisher reference, volume number and page location. (MUT) 3¢-UTR sequences of HOTAIR were inserted at the firefly luciferase gene in pRL-CMV vectors (Promega, Madison, WI, USA), purified, and named as reporter mimics.

Article Title: Differential response of nucleus pulposus intervertebral disc cells to high salt, sorbitol, and urea.
Article Snippet: Nucleus pulposus intervertebral disc cells are routinely confronted with high osmolality in their microenvironment and respond to this stress in vitro by regulating cell cycle progression and by activating a DNA repair machinery in order to counteract its genotoxic effect.. In the present study, we attempted to identify the origin of this osmo-regulatory response, by using an ionic NaCl/KCl solution, the compatible osmolyte sorbitol, and the readily permeant urea.. High salt and sorbitol were found to activate similar molecular pathways, including the p38MAPK and the p53-p21-pRb axis, thatwere not stimulated by high urea.On the other hand, only high urea led to the phosphorylation of ERKs and JNKs.

Article Title: STK25 is an IRF5 kinase that promotes TLR7/8-mediated inflammation
Article Snippet: The pGL3-ISRE-Luc vector and the pRL-CMV vectors were obtained from Promega.

Article Title: TLR-induced STK25 activation promotes IRF5-mediated inflammation.
Article Snippet: The pGL3-ISRE-Luc vector and the pRL-CMV vectors were obtained from Promega.

Article Title: Ribosomal protein S15a promotes tumor angiogenesis via enhancing Wnt/β-catenin-induced FGF18 expression in hepatocellular carcinoma.
Article Snippet: Ribosomal protein s15a (RPS15A) plays a promotive role in the mRNA/ribosome interactions during early translation.. Our previous study has found that inhibiting RPS15A expression can decrease proliferation and induce cell cycle arrest in hepatocellular carcinoma (HCC) cell lines.. However, the mechanism underlying the involvement of RPS15A in HCC pathogenesis and the clinical significance of RPS15A expression remain unclear.

Cell Culture:

Article Title: Long Noncoding RNA HOTAIR: An Oncogene in Human Cervical Cancer Interacting With MicroRNA-17-5p
Article Snippet: In the preparatory stage, wild-type (WT) or mutant-type (MUT) 3′-UTR sequences of HOTAIR were inserted at the firefly luciferase gene in pRL-CMV vectors (Promega, Madison, WI, USA), purified, and named as reporter mimics.

Article Title: Long Noncoding RNA HOTAIR: An Oncogene in Human Cervical Cancer Interacting With MicroRNA-17-5p
Article Snippet: In addition, pRL-CML vectors carrying the Renilla luciferase gene were applied in every sample as internal control for transfection efficiency (Promega).

Article Title: High glucose/ChREBP-induced Hif-1α transcriptional activation in CD4 + T cells reduces the risk of diabetic kidney disease by inhibiting the Th1 response.
Article Snippet: Dual luciferase reporter assay 293T cells were cultured in 24 well plates overnight and then transfected with the pGL3 vector reporter construct and pRL-CMV vectors (Promega, USA) encoding Renilla luciferase using lipofectamine 2000 reagent (Invitrogen).

Article Title: Long Noncoding RNA HOTAIR: An Oncogene in Human Cervical Cancer Interacting With MicroRNA-17-5p
Article Snippet: Please use proper citation format when citing this article including the DOI, publisher reference, volume number and page location. (MUT) 3¢-UTR sequences of HOTAIR were inserted at the firefly luciferase gene in pRL-CMV vectors (Promega, Madison, WI, USA), purified, and named as reporter mimics.

Article Title: Differential response of nucleus pulposus intervertebral disc cells to high salt, sorbitol, and urea.
Article Snippet: Nucleus pulposus intervertebral disc cells are routinely confronted with high osmolality in their microenvironment and respond to this stress in vitro by regulating cell cycle progression and by activating a DNA repair machinery in order to counteract its genotoxic effect.. In the present study, we attempted to identify the origin of this osmo-regulatory response, by using an ionic NaCl/KCl solution, the compatible osmolyte sorbitol, and the readily permeant urea.. High salt and sorbitol were found to activate similar molecular pathways, including the p38MAPK and the p53-p21-pRb axis, thatwere not stimulated by high urea.On the other hand, only high urea led to the phosphorylation of ERKs and JNKs.

Article Title: STK25 is an IRF5 kinase that promotes TLR7/8-mediated inflammation
Article Snippet: The pGL3-ISRE-Luc vector and the pRL-CMV vectors were obtained from Promega.

Article Title: TLR-induced STK25 activation promotes IRF5-mediated inflammation.
Article Snippet: The pGL3-ISRE-Luc vector and the pRL-CMV vectors were obtained from Promega.

Article Title: Ribosomal protein S15a promotes tumor angiogenesis via enhancing Wnt/β-catenin-induced FGF18 expression in hepatocellular carcinoma.
Article Snippet: Ribosomal protein s15a (RPS15A) plays a promotive role in the mRNA/ribosome interactions during early translation.. Our previous study has found that inhibiting RPS15A expression can decrease proliferation and induce cell cycle arrest in hepatocellular carcinoma (HCC) cell lines.. However, the mechanism underlying the involvement of RPS15A in HCC pathogenesis and the clinical significance of RPS15A expression remain unclear.

Transfection:

Article Title: Long Noncoding RNA HOTAIR: An Oncogene in Human Cervical Cancer Interacting With MicroRNA-17-5p
Article Snippet: In the preparatory stage, wild-type (WT) or mutant-type (MUT) 3′-UTR sequences of HOTAIR were inserted at the firefly luciferase gene in pRL-CMV vectors (Promega, Madison, WI, USA), purified, and named as reporter mimics.

Article Title: Long Noncoding RNA HOTAIR: An Oncogene in Human Cervical Cancer Interacting With MicroRNA-17-5p
Article Snippet: In addition, pRL-CML vectors carrying the Renilla luciferase gene were applied in every sample as internal control for transfection efficiency (Promega).

Article Title: High glucose/ChREBP-induced Hif-1α transcriptional activation in CD4 + T cells reduces the risk of diabetic kidney disease by inhibiting the Th1 response.
Article Snippet: Dual luciferase reporter assay 293T cells were cultured in 24 well plates overnight and then transfected with the pGL3 vector reporter construct and pRL-CMV vectors (Promega, USA) encoding Renilla luciferase using lipofectamine 2000 reagent (Invitrogen).

Article Title: Long Noncoding RNA HOTAIR: An Oncogene in Human Cervical Cancer Interacting With MicroRNA-17-5p
Article Snippet: Please use proper citation format when citing this article including the DOI, publisher reference, volume number and page location. (MUT) 3¢-UTR sequences of HOTAIR were inserted at the firefly luciferase gene in pRL-CMV vectors (Promega, Madison, WI, USA), purified, and named as reporter mimics.

Article Title: Differential response of nucleus pulposus intervertebral disc cells to high salt, sorbitol, and urea.
Article Snippet: Nucleus pulposus intervertebral disc cells are routinely confronted with high osmolality in their microenvironment and respond to this stress in vitro by regulating cell cycle progression and by activating a DNA repair machinery in order to counteract its genotoxic effect.. In the present study, we attempted to identify the origin of this osmo-regulatory response, by using an ionic NaCl/KCl solution, the compatible osmolyte sorbitol, and the readily permeant urea.. High salt and sorbitol were found to activate similar molecular pathways, including the p38MAPK and the p53-p21-pRb axis, thatwere not stimulated by high urea.On the other hand, only high urea led to the phosphorylation of ERKs and JNKs.

Article Title: STK25 is an IRF5 kinase that promotes TLR7/8-mediated inflammation
Article Snippet: The pGL3-ISRE-Luc vector and the pRL-CMV vectors were obtained from Promega.

Article Title: TLR-induced STK25 activation promotes IRF5-mediated inflammation.
Article Snippet: The pGL3-ISRE-Luc vector and the pRL-CMV vectors were obtained from Promega.

Article Title: Ribosomal protein S15a promotes tumor angiogenesis via enhancing Wnt/β-catenin-induced FGF18 expression in hepatocellular carcinoma.
Article Snippet: Ribosomal protein s15a (RPS15A) plays a promotive role in the mRNA/ribosome interactions during early translation.. Our previous study has found that inhibiting RPS15A expression can decrease proliferation and induce cell cycle arrest in hepatocellular carcinoma (HCC) cell lines.. However, the mechanism underlying the involvement of RPS15A in HCC pathogenesis and the clinical significance of RPS15A expression remain unclear.

Construct:

Article Title: Long Noncoding RNA HOTAIR: An Oncogene in Human Cervical Cancer Interacting With MicroRNA-17-5p
Article Snippet: In the preparatory stage, wild-type (WT) or mutant-type (MUT) 3′-UTR sequences of HOTAIR were inserted at the firefly luciferase gene in pRL-CMV vectors (Promega, Madison, WI, USA), purified, and named as reporter mimics.

Article Title: Long Noncoding RNA HOTAIR: An Oncogene in Human Cervical Cancer Interacting With MicroRNA-17-5p
Article Snippet: In addition, pRL-CML vectors carrying the Renilla luciferase gene were applied in every sample as internal control for transfection efficiency (Promega).

Article Title: High glucose/ChREBP-induced Hif-1α transcriptional activation in CD4 + T cells reduces the risk of diabetic kidney disease by inhibiting the Th1 response.
Article Snippet: Dual luciferase reporter assay 293T cells were cultured in 24 well plates overnight and then transfected with the pGL3 vector reporter construct and pRL-CMV vectors (Promega, USA) encoding Renilla luciferase using lipofectamine 2000 reagent (Invitrogen).

Article Title: Long Noncoding RNA HOTAIR: An Oncogene in Human Cervical Cancer Interacting With MicroRNA-17-5p
Article Snippet: Please use proper citation format when citing this article including the DOI, publisher reference, volume number and page location. (MUT) 3¢-UTR sequences of HOTAIR were inserted at the firefly luciferase gene in pRL-CMV vectors (Promega, Madison, WI, USA), purified, and named as reporter mimics.

Article Title: Differential response of nucleus pulposus intervertebral disc cells to high salt, sorbitol, and urea.
Article Snippet: Nucleus pulposus intervertebral disc cells are routinely confronted with high osmolality in their microenvironment and respond to this stress in vitro by regulating cell cycle progression and by activating a DNA repair machinery in order to counteract its genotoxic effect.. In the present study, we attempted to identify the origin of this osmo-regulatory response, by using an ionic NaCl/KCl solution, the compatible osmolyte sorbitol, and the readily permeant urea.. High salt and sorbitol were found to activate similar molecular pathways, including the p38MAPK and the p53-p21-pRb axis, thatwere not stimulated by high urea.On the other hand, only high urea led to the phosphorylation of ERKs and JNKs.

Article Title: STK25 is an IRF5 kinase that promotes TLR7/8-mediated inflammation
Article Snippet: The pGL3-ISRE-Luc vector and the pRL-CMV vectors were obtained from Promega.

Article Title: TLR-induced STK25 activation promotes IRF5-mediated inflammation.
Article Snippet: The pGL3-ISRE-Luc vector and the pRL-CMV vectors were obtained from Promega.

Article Title: Ribosomal protein S15a promotes tumor angiogenesis via enhancing Wnt/β-catenin-induced FGF18 expression in hepatocellular carcinoma.
Article Snippet: Ribosomal protein s15a (RPS15A) plays a promotive role in the mRNA/ribosome interactions during early translation.. Our previous study has found that inhibiting RPS15A expression can decrease proliferation and induce cell cycle arrest in hepatocellular carcinoma (HCC) cell lines.. However, the mechanism underlying the involvement of RPS15A in HCC pathogenesis and the clinical significance of RPS15A expression remain unclear.

Purification:

Article Title: Long Noncoding RNA HOTAIR: An Oncogene in Human Cervical Cancer Interacting With MicroRNA-17-5p
Article Snippet: In the preparatory stage, wild-type (WT) or mutant-type (MUT) 3′-UTR sequences of HOTAIR were inserted at the firefly luciferase gene in pRL-CMV vectors (Promega, Madison, WI, USA), purified, and named as reporter mimics.

Article Title: Long Noncoding RNA HOTAIR: An Oncogene in Human Cervical Cancer Interacting With MicroRNA-17-5p
Article Snippet: In addition, pRL-CML vectors carrying the Renilla luciferase gene were applied in every sample as internal control for transfection efficiency (Promega).

Article Title: High glucose/ChREBP-induced Hif-1α transcriptional activation in CD4 + T cells reduces the risk of diabetic kidney disease by inhibiting the Th1 response.
Article Snippet: Dual luciferase reporter assay 293T cells were cultured in 24 well plates overnight and then transfected with the pGL3 vector reporter construct and pRL-CMV vectors (Promega, USA) encoding Renilla luciferase using lipofectamine 2000 reagent (Invitrogen).

Article Title: Long Noncoding RNA HOTAIR: An Oncogene in Human Cervical Cancer Interacting With MicroRNA-17-5p
Article Snippet: Please use proper citation format when citing this article including the DOI, publisher reference, volume number and page location. (MUT) 3¢-UTR sequences of HOTAIR were inserted at the firefly luciferase gene in pRL-CMV vectors (Promega, Madison, WI, USA), purified, and named as reporter mimics.

Article Title: Differential response of nucleus pulposus intervertebral disc cells to high salt, sorbitol, and urea.
Article Snippet: Nucleus pulposus intervertebral disc cells are routinely confronted with high osmolality in their microenvironment and respond to this stress in vitro by regulating cell cycle progression and by activating a DNA repair machinery in order to counteract its genotoxic effect.. In the present study, we attempted to identify the origin of this osmo-regulatory response, by using an ionic NaCl/KCl solution, the compatible osmolyte sorbitol, and the readily permeant urea.. High salt and sorbitol were found to activate similar molecular pathways, including the p38MAPK and the p53-p21-pRb axis, thatwere not stimulated by high urea.On the other hand, only high urea led to the phosphorylation of ERKs and JNKs.

Article Title: STK25 is an IRF5 kinase that promotes TLR7/8-mediated inflammation
Article Snippet: The pGL3-ISRE-Luc vector and the pRL-CMV vectors were obtained from Promega.

Article Title: TLR-induced STK25 activation promotes IRF5-mediated inflammation.
Article Snippet: The pGL3-ISRE-Luc vector and the pRL-CMV vectors were obtained from Promega.

Article Title: Ribosomal protein S15a promotes tumor angiogenesis via enhancing Wnt/β-catenin-induced FGF18 expression in hepatocellular carcinoma.
Article Snippet: Ribosomal protein s15a (RPS15A) plays a promotive role in the mRNA/ribosome interactions during early translation.. Our previous study has found that inhibiting RPS15A expression can decrease proliferation and induce cell cycle arrest in hepatocellular carcinoma (HCC) cell lines.. However, the mechanism underlying the involvement of RPS15A in HCC pathogenesis and the clinical significance of RPS15A expression remain unclear.

Control:

Article Title: Long Noncoding RNA HOTAIR: An Oncogene in Human Cervical Cancer Interacting With MicroRNA-17-5p
Article Snippet: In the preparatory stage, wild-type (WT) or mutant-type (MUT) 3′-UTR sequences of HOTAIR were inserted at the firefly luciferase gene in pRL-CMV vectors (Promega, Madison, WI, USA), purified, and named as reporter mimics.

Article Title: Long Noncoding RNA HOTAIR: An Oncogene in Human Cervical Cancer Interacting With MicroRNA-17-5p
Article Snippet: In addition, pRL-CML vectors carrying the Renilla luciferase gene were applied in every sample as internal control for transfection efficiency (Promega).

Article Title: High glucose/ChREBP-induced Hif-1α transcriptional activation in CD4 + T cells reduces the risk of diabetic kidney disease by inhibiting the Th1 response.
Article Snippet: Dual luciferase reporter assay 293T cells were cultured in 24 well plates overnight and then transfected with the pGL3 vector reporter construct and pRL-CMV vectors (Promega, USA) encoding Renilla luciferase using lipofectamine 2000 reagent (Invitrogen).

Article Title: Long Noncoding RNA HOTAIR: An Oncogene in Human Cervical Cancer Interacting With MicroRNA-17-5p
Article Snippet: Please use proper citation format when citing this article including the DOI, publisher reference, volume number and page location. (MUT) 3¢-UTR sequences of HOTAIR were inserted at the firefly luciferase gene in pRL-CMV vectors (Promega, Madison, WI, USA), purified, and named as reporter mimics.

Article Title: Differential response of nucleus pulposus intervertebral disc cells to high salt, sorbitol, and urea.
Article Snippet: Nucleus pulposus intervertebral disc cells are routinely confronted with high osmolality in their microenvironment and respond to this stress in vitro by regulating cell cycle progression and by activating a DNA repair machinery in order to counteract its genotoxic effect.. In the present study, we attempted to identify the origin of this osmo-regulatory response, by using an ionic NaCl/KCl solution, the compatible osmolyte sorbitol, and the readily permeant urea.. High salt and sorbitol were found to activate similar molecular pathways, including the p38MAPK and the p53-p21-pRb axis, thatwere not stimulated by high urea.On the other hand, only high urea led to the phosphorylation of ERKs and JNKs.

Article Title: STK25 is an IRF5 kinase that promotes TLR7/8-mediated inflammation
Article Snippet: The pGL3-ISRE-Luc vector and the pRL-CMV vectors were obtained from Promega.

Article Title: TLR-induced STK25 activation promotes IRF5-mediated inflammation.
Article Snippet: The pGL3-ISRE-Luc vector and the pRL-CMV vectors were obtained from Promega.

Article Title: Ribosomal protein S15a promotes tumor angiogenesis via enhancing Wnt/β-catenin-induced FGF18 expression in hepatocellular carcinoma.
Article Snippet: Ribosomal protein s15a (RPS15A) plays a promotive role in the mRNA/ribosome interactions during early translation.. Our previous study has found that inhibiting RPS15A expression can decrease proliferation and induce cell cycle arrest in hepatocellular carcinoma (HCC) cell lines.. However, the mechanism underlying the involvement of RPS15A in HCC pathogenesis and the clinical significance of RPS15A expression remain unclear.

Mutagenesis:

Article Title: Long Noncoding RNA HOTAIR: An Oncogene in Human Cervical Cancer Interacting With MicroRNA-17-5p
Article Snippet: In the preparatory stage, wild-type (WT) or mutant-type (MUT) 3′-UTR sequences of HOTAIR were inserted at the firefly luciferase gene in pRL-CMV vectors (Promega, Madison, WI, USA), purified, and named as reporter mimics.

Article Title: Long Noncoding RNA HOTAIR: An Oncogene in Human Cervical Cancer Interacting With MicroRNA-17-5p
Article Snippet: In addition, pRL-CML vectors carrying the Renilla luciferase gene were applied in every sample as internal control for transfection efficiency (Promega).

Article Title: High glucose/ChREBP-induced Hif-1α transcriptional activation in CD4 + T cells reduces the risk of diabetic kidney disease by inhibiting the Th1 response.
Article Snippet: Dual luciferase reporter assay 293T cells were cultured in 24 well plates overnight and then transfected with the pGL3 vector reporter construct and pRL-CMV vectors (Promega, USA) encoding Renilla luciferase using lipofectamine 2000 reagent (Invitrogen).

Article Title: Long Noncoding RNA HOTAIR: An Oncogene in Human Cervical Cancer Interacting With MicroRNA-17-5p
Article Snippet: Please use proper citation format when citing this article including the DOI, publisher reference, volume number and page location. (MUT) 3¢-UTR sequences of HOTAIR were inserted at the firefly luciferase gene in pRL-CMV vectors (Promega, Madison, WI, USA), purified, and named as reporter mimics.

Article Title: Differential response of nucleus pulposus intervertebral disc cells to high salt, sorbitol, and urea.
Article Snippet: Nucleus pulposus intervertebral disc cells are routinely confronted with high osmolality in their microenvironment and respond to this stress in vitro by regulating cell cycle progression and by activating a DNA repair machinery in order to counteract its genotoxic effect.. In the present study, we attempted to identify the origin of this osmo-regulatory response, by using an ionic NaCl/KCl solution, the compatible osmolyte sorbitol, and the readily permeant urea.. High salt and sorbitol were found to activate similar molecular pathways, including the p38MAPK and the p53-p21-pRb axis, thatwere not stimulated by high urea.On the other hand, only high urea led to the phosphorylation of ERKs and JNKs.

Article Title: STK25 is an IRF5 kinase that promotes TLR7/8-mediated inflammation
Article Snippet: The pGL3-ISRE-Luc vector and the pRL-CMV vectors were obtained from Promega.

Article Title: TLR-induced STK25 activation promotes IRF5-mediated inflammation.
Article Snippet: The pGL3-ISRE-Luc vector and the pRL-CMV vectors were obtained from Promega.

Article Title: Ribosomal protein S15a promotes tumor angiogenesis via enhancing Wnt/β-catenin-induced FGF18 expression in hepatocellular carcinoma.
Article Snippet: Ribosomal protein s15a (RPS15A) plays a promotive role in the mRNA/ribosome interactions during early translation.. Our previous study has found that inhibiting RPS15A expression can decrease proliferation and induce cell cycle arrest in hepatocellular carcinoma (HCC) cell lines.. However, the mechanism underlying the involvement of RPS15A in HCC pathogenesis and the clinical significance of RPS15A expression remain unclear.



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